BioNTech Teams Up with Bristol Myers Squibb for a Blockbuster Cancer Drug Partnership
Pharmaceutical company BioNTech clinches multi-billion-dollar drug transaction
German biotech giant, BioNTech, has joined forces with the US pharmaceutical behemoth, Bristol Myers Squibb (BMS), in a groundbreaking collaboration to bring BNT327, an experimental cancer drug, to the market. The multibillion-dollar deal is poised to revolutionize the oncology landscape.
The Financial Nitty-Gritty
The initial payment from BMS to BioNTech stands at a whopping $1.5 billion, payable soon. The potential value of this partnership could surpass $11 billion for BioNTech. Beyond this upfront payment, BMS will make further annual milestone payments of up to $2 billion by 2028.
Additionally, BioNTech could receive up to an additional $7.6 billion through milestone payments for development, approvals, and commercialization. The companies will share the development and manufacturing costs, as well as any associated profits and losses, equally.
BNT327: Next-Generation Immunotherapy
BNT327 is a cutting-edge antibody that belongs to a new class of immunotherapies. It harnesses the patient's immune system to fight various diseases, particularly cancer. This drug is currently in Phase 3 trials for both small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). A third late-stage trial for triple-negative breast cancer is scheduled to kick off by the end of the year.
Clinical Trials and Indications
BNT327 is designed to target two critical proteins in cancer therapy: PD-L1 and VEGF. It is being investigated in combination with chemotherapy for untreated SCLC. A clinical study is also underway to evaluate the combination of BNT327 with BNT324, a B7-H3 antibody-drug conjugate, in patients with advanced lung cancer.
A Race for Revolutionary Treatment
This partnership places both companies at the forefront of the emerging bispecific antibody market. Their shared goal is to develop foundational immuno-oncology treatments in this increasingly competitive landscape. Alongside this collaboration, US biotech company Instil Bio and Chinese competitor ImmuneOnco are working on a similar drug called SYN-2510. Another partnership, formed by Summit Therapeutics and Akeso, is spearheading the development of a drug candidate named Ivonescimab.
[1] ntv.de, lar/rts[2] BioNTech Press Release, April 6, 2022[3] BioNTech Clinical Trial Database, accessed May 2022
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The collaboration between BioNTech and Bristol Myers Squibb revolves around the employment policy of both companies, as they aim to equally share the development and manufacturing costs, as well as any associated profits and losses, within the employment structure. This partnership, valued at over $11 billion for BioNTech, is financed mainly by an initial payment of $1.5 billion from Bristol Myers Squibb, with further annual milestone payments up to $2 billion by 2028, and potential additional payments up to $7.6 billion for development, approvals, and commercialization. The focus of this business partnership is the development of BNT327, an experimental cancer drug that belongs to a new class of immunotherapies.
